Women who received estrogen through a skin patch had lower brain amyloid deposition than women who received a placebo, while oral estrogen was not associated with lower amyloid deposition.
Notes on verification
Confirmed by peer-reviewed journal article (Kantarci et al., 2016, Journal of Alzheimer's Disease) and independent press release, with consistent findings on transdermal vs oral estrogen effects on amyloid deposition in the KEEPS study. [cascade flags: aggregator_dropped_primary_exists | tier=silver indep_score=0.925 clusters=2 claim_tier=notable]
Sources
- Estrogen Patch in Newly Postmenopausal Women May Reduce ... (seed:health_and_medicine)
- https://dx.doi.org/10.3233/JAD-160258 (corroboration)
- https://ncbi.nlm.nih.gov/sites/ppmc/articles/PMC4955514 (corroboration)