The NIA Interventions Testing Program found that acarbose significantly extended lifespan in both sexes of UM-HET3 mice, but the effect was much greater in males than in females (Harrison et al., 2014).
Notes on verification
Confirmed directly by the original Harrison et al. 2014 Aging Cell paper and NIA press release, with independent corroboration from multiple follow-up studies (Garratt 2017, Dodds 2020, Harrison 2019). No contradictions found. [tier=silver indep_score=0.77 clusters=2 claim_tier=notable]
Sources
- NIA Interventions Testing Program: Investigating Putative ... (seed:health_and_medicine)
- https://onlinelibrary.wiley.com/doi/10.1111/acel.12170 (corroboration)
- https://www.sciencedirect.com/science/article/pii/S2352396416305540 (corroboration)