Rapamycin extended lifespan in both male and female UM-HET3 mice, with females showing a greater benefit than males (Harrison et al., 2009; Miller et al., 2011, 2014).
Notes on verification
Confirmed by primary peer-reviewed sources (Harrison et al. 2009, Nature; Miller et al. 2011, 2014, Aging Cell) and corroborated by independent secondary reviews (eLife 2016, SpringerPlus 2015) explicitly citing the same trio of studies for the sex-dimorphic lifespan extension effect. [tier=gold indep_score=1.0 clusters=4 claim_tier=notable]
Sources
- NIA Interventions Testing Program: Investigating Putative ... (seed:health_and_medicine)
- https://www.nature.com/articles/nature08221 (corroboration)
- https://onlinelibrary.wiley.com/doi/10.1111/acel.12194 (corroboration)
- https://elifesciences.org/articles/16351 (corroboration)
- https://springerplus.springeropen.com/articles/10.1186/s40064-015-0909-7 (corroboration)