People with cluster headache tend to have higher cortisol and lower melatonin levels compared to individuals without headache disorders.
Notes on verification
Confirmed by multiple independent peer-reviewed studies (Leone et al. 1995, Chazot et al. 1984) and a 2020 meta-analysis (Liampas et al.) showing consistent findings of decreased melatonin and altered/increased cortisol rhythms in cluster headache patients vs controls. [tier=silver indep_score=1.0 clusters=2 claim_tier=notable]
Sources
- Migraine and Cluster Headaches are Linked to the Body's Internal ... (seed:health_and_medicine)
- https://pubmed.ncbi.nlm.nih.gov/7553813/ (corroboration)
- https://journals.sagepub.com/doi/10.1046/j.1468-2982.1995.015003224.x (corroboration)
- https://pubmed.ncbi.nlm.nih.gov/6518501/ (corroboration)