Nordihydroguaiaretic acid (NDGA) failed to extend lifespan in female mice even at doses producing blood levels similar to those in males, and extended lifespan only in males (Harrison et al., 2014).
Notes on verification
Confirmed by the primary Harrison et al. 2014 Aging Cell paper and corroborated by multiple independent secondary sources summarizing the same sex-specific lifespan extension findings. [tier=gold indep_score=0.9 clusters=4 claim_tier=notable]
Sources
- NIA Interventions Testing Program: Investigating Putative ... (seed:health_and_medicine)
- https://onlinelibrary.wiley.com/doi/10.1111/acel.12170 (corroboration)
- https://www.alzdiscovery.org/uploads/cognitive_vitality_media/NDGA-Cognitive-Vitality-For-Researchers.pdf (corroboration)
- https://fastlifehacks.com/life-extending-drugs-from-itp-trials/ (corroboration)
- https://scholars.uthscsa.edu/en/publications/nordihydroguaiaretic-acid-and-aspirin-increase-lifespan-of-geneti (corroboration)