Science1999-2001United Stateshigh confidence

In the UCSD sleep deprivation study, fMRI showed less activity in the prefrontal cortex during a sleep-deprived arithmetic task, a region associated with working-memory functioning.

Notes on verification

Confirmed by peer-reviewed publication (NeuroReport 1999) and APA Monitor coverage, with additional corroboration in follow-up neuroimaging literature. [tier=gold indep_score=0.983 clusters=3 claim_tier=notable]

Sources