In a small phase I clinical trial, a combination of the cancer drug dasatinib and the plant pigment quercetin eliminated senescent cells from the tissues of people with diabetic kidney disease.
Notes on verification
Confirmed by peer-reviewed primary source (Hickson et al., EBioMedicine 2019) and corroborating secondary sources. Claim's phrase 'eliminated' overstates the actual finding of significant reduction rather than complete elimination; trial was small (n=9) and open-label, limiting generalizability. [tier=gold indep_score=0.983 clusters=3 claim_tier=notable]
Sources
- Is There a Cure for Aging? (seed:health_and_medicine)
- https://www.alzforum.org/therapeutics/dasatinib-quercetin (corroboration)
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796530/ (corroboration)
- https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30591-2/fulltext (corroboration)