Caffeine in cocoa may block the effects of dipyridamole (Persantine) or adenosine (Adenocard) used in cardiac stress tests.
Notes on verification
Well-corroborated by peer-reviewed cardiology/nuclear medicine literature and clinical drug interaction databases; mechanism (adenosine receptor antagonism by caffeine) is well-established pharmacology, though clinical significance varies between dipyridamole (more affected) and adenosine (less consistently affected). [cascade flags: aggregator_dropped_primary_exists | tier=silver indep_score=0.97 clusters=5 claim_tier=notable | kind=empirical eligibility=high (extractor: empirical/medium)]
Sources
- Cocoa - Uses, Side Effects, and More - WebMD (seed:health_and_medicine)
- https://www.rxlist.com/supplements/cocoa.htm (corroboration)
- https://www.drugs.com/interactions-check.php?drug_list=105-0,914-0&professional=1 (corroboration)
- https://www.ncbi.nlm.nih.gov/books/NBK555963/ (corroboration)
- https://www.drugs.com/food-interactions/dipyridamole,persantine.html (corroboration)
- https://www.sciencedirect.com/science/article/abs/pii/S1071358104001412 (corroboration)
- https://www.urmc.rochester.edu/conditions-and-treatments/nuclear-cardiology (corroboration)