Both cluster headaches and migraine have been associated with circadian genes and altered levels of circadian-related hormones, including cortisol and melatonin.
Notes on verification
Confirmed by multiple independent peer-reviewed sources, including a 2023 Neurology systematic review/meta-analysis and AAN press release, plus older supporting studies on melatonin and cortisol dysregulation in cluster headache and migraine. [tier=gold indep_score=0.925 clusters=4 claim_tier=notable]
Sources
- Migraine and Cluster Headaches are Linked to the Body's Internal ... (seed:health_and_medicine)
- https://www.neurology.org/doi/10.1212/WNL.0000000000207240 (corroboration)
- https://www.aan.com/PressRoom/Home/PressRelease/5067 (corroboration)
- https://pubmed.ncbi.nlm.nih.gov/11858532/ (corroboration)
- https://onlinelibrary.wiley.com/doi/10.1111/ane.13317 (corroboration)